FZD3 and colorectal carcinoma: To test our hypothesis of inhibiting FZD receptors, the expression levels of each of the 10 FZD receptor family members were compared between normal and cancerous colorectal tissues using the Gene Expression Display Server (GEDS) and found that FZD receptors have higher expression levels in cancerous tissues than normal tissues, with some receptors having a higher expression level in CRC than others such as FZD3 (Fig. 4).