It is also the primary pathology seen in sporadic ALS, most familial forms of ALS (with the exception of FUS and SOD1 mutations), and 50% of sporadic and familial FTD cases [47, 48], and has also been described in other neurodegenerative diseases, such as Alzheimer’s disease [40, 45]. Here, FUS is linked to amyotrophic lateral sclerosis.