TARDBP and amyotrophic lateral sclerosis: To elucidate transcriptional differences, including TDP-43-associated CE inclusion, at a cell-specific level, we performed snRNA-seq on the frontal (disease-affected) and occipital (a less affected brain region) cortices of 12 neurologically normal controls and 25 C9ORF72 patients whose clinical diagnosis spanned the ALS-FTD spectrum (C9-ALS n = 10, C9-ALS/FTD n = 6, C9-FTD n = 9) (Fig. 1a and Table 1; Supplementary Table 1, online resource).