This is of particular interest in FTD-TDP where the cell types of the frontal cortex that are impacted by TDP-43 pathology are less well-defined than the cells of the spinal cord, motor cortex and brainstem motor nuclei that are known to be susceptible to TDP-43 pathology in ALS-TDP. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.