TARDBP and frontotemporal dementia: In this study, we performed single-nuclei RNA sequencing (snRNA-seq) on the frontal cortex of C9ORF72 mutation carriers that spanned the ALS-FTD phenotypic spectrum (C9-ALS, C9-ALS/FTD, C9-FTD) to identify individual cells that contained CEs in known splicing targets of TDP-43.