UBC and periodontitis: The proteins encoded by UBC gene are mainly responsible for regulating transduction signal and protein degradation, playing an important part in regulating the innate and adaptive host immune responses.35,36 This way, its entirety is well-established by biological processes involved in periodontitis pathogenesis, like the MAPK pathway, antigen processing and presentation via MHC-I, and apoptotic processes, being reported as an important gene for periodontitis in an interactome study.37