KRT25 and airway hyperresponsiveness: However, the SNV rs72821893 (KRT25) was recently associated with the individual’s response to asthma treatment.29 Leusink, et al.29 (2016), when studying a population of 110 children with asthma diagnosis that was not well controlled despite inhaled corticosteroid (ICS) treatment and the 17q12-21 locus – previously associated with childhood asthma – found that the rs72821893 in KRT25 gene was associated with the lung function and airway hyperresponsiveness (AHR) to methacholine, and additionally with ICS treatment response.29