MAPT and tauopathy: The dissociation of tau from microtubulesis considered the leading cause of its pathological accumulation;however, the molecular mechanisms involved in the early events ofpathogenesis are still not completely clear.11 Due to the increase in the elderly population, the number of patientswith tauopathies expected in the future years is very high: this willrepresent a high socio-economic burden worldwide unless the meansto prevent or treat these diseases are found.