MAPT and early-onset autosomal dominant Alzheimer disease: Espresso coffee isamong the most consumed beverages in the world.Recent studies report a protective activity of the coffee beverageagainst neurodegenerative disorders such as Alzheimer′s disease.Alzheimer′s disease belongs to a group of disorders, calledtauopathies, which are characterized by the intraneuronal accumulationof the microtubule-associated protein tau in fibrillar aggregates.In this work, we characterized by NMR the molecular composition ofthe espresso coffee extract and identified its main components.