NPY2R and obesity due to melanocortin 4 receptor deficiency: Specifically, the mislocalization of some receptors, such as neuropeptide Y receptor Y2 (NPY2R), serotonin 5-hydroxytryptamine (HT)2C receptor (5-HT2CR), and leptin receptor, in the hypothalamus may lead to hyperphagia and obesity (Guo et al., 2019; Guo et al., 2016; Seo et al., 2009).