Given that previous canonical CerS-deficient mouse models failed to display retinal degeneration (Brüggen et al., 2016), an interesting question was brought up regarding the relationship between ceramide homeostasis and retinal cell death in the context of TLCD3B deficiency: is TLCD3B deficiency-associated retinal cell death caused by an absolute change in ceramide level, or does a healthy retina rely more on the profile maintenance of different ceramide species with variable chain lengths? Here, TLCD3B is linked to retinal degeneration.