To this end, they compared the secretome of low‐autophagy melanoma cells and their high‐autophagy metastatic derivative, and confirmed their observations in serum of metastatic melanoma patients, identifying IL‐1β, CXCL8 (chemokine (C‐X‐C motif) ligand 8), LIF (leukemia inhibitory factor), FAM3C (family with sequence similarity 3, member C), and DKK3 (dickkopf WNT signaling pathway inhibitor 3). Here, DKK3 is linked to metastatic melanoma.