The etiology of angioedema includes three general causes: mast-cell mediated allergic angioedema, hereditary angioedema, and angiotensin converting enzyme inhibitor (ACE-I) induced angioedema.2 Facial skin is the most likely to be affected by angioedema, but it may also involve the gastrointestinal tract and upper airways, necessitating swift evaluation and intervention by the emergency physician. Here, ACE is linked to angioedema.