KLK4 and angioedema: 5 Given that our patient was on lisinopril, an ACE-i, and reported prior lip swelling with cinnamon consumption, she was treated primarily as ACE-i induced angioedema versus mast-cell mediated angioedema. Steroids and antihistamines were administered to suppress the mast-cell mediated angioedema. She was also treated with tranexamic acid (TXA), an antifibrinolytic agent which inhibits conversion of plasminogen to plasmin. Tranexamic acid is thought to reduce bradykinin mediated angioedema since plasmin is a key step in kallikrein activation and bradykinin formation.6