reported that biomarkers (ACE2, NF-κB, NOX4, ASC), pyroptosis and inflammasome-derived cytokines such as IL-18 and caspase-1 were all significantly increased in the COVID-19 group via immunohistochemistry of lung tissue from patients who died of SARS-CoV-2 infection (Baena Carstens et al., 2022). The gene discussed is CASP1; the disease is COVID-19.