NLRP3 and infection: As reported by Yalcinkaya M et al., the E protein of SARS-CoV-2 may initially inhibit the response of host NLRP3 inflammasome to viral RNA, but may increase the response of NLRP3 inflammasome in the later stage of infection both in human macrophages and mice model (Yalcinkaya et al., 2021).