NLRP3 and brain disorder: On the other hand, NLRP3 inflammasome promotes pyroptosis of “bystander” CD4+ T cells (Montague-Cardoso, 2021; Zhang C. et al., 2021) and causes brain disease and neuroinflammation that are closely associated with NLRP3 inflammasome activation in microglia (Walsh et al., 2014; He et al., 2020).