AGT and Hypertension: Kassan et al. (2011) provided evidence that Tregs played a protective role through IL-10, demonstrating its ability to slightly improve the endothelium-dependent vasodilator response to hypertension. Tinsley et al. (2010) found that daily intraperitoneal injection of recombinant IL-10 restored normal blood pressure in pregnant rats with pregnancy-induced hypertension. Notably, IL-10 is known to have a vascular protection function, which can limit the vascular injury caused by Ang II (Barhoumi et al., 2011).