As shown in (Supplementary Figure 4B), through its interaction with peptidoglycan (G+) lipoprotein and zymoglycan, TLR2 binds to downstream NF-kappaB via the P13K-AKt signaling pathway, promoting the synthesis of pro-inflammatory factors such as IL-1B and IL-6, thus exacerbating the progression of ANCA-GN. Here, IL1B is linked to ganglioneuroma.