Furthermore, some studies have shown that plasmid-encoded peptides from Staphylococcus aureus can induce autoimmune glomerulonephritis by inducing anti-myeloperoxidase antibodies (38), indicating that toll-like receptor signaling pathway and Staphylococcus aureus infection may be involved in the pathogenesis and development of ANCA-GN. This evidence concerns the gene MPO and ganglioneuroma.