First, a clinical diagnostic model for ANCA-GN was constructed based on the expression levels of 6 NRGs (CYBB, ITGB2, ITGAM, TLR2, TLR7, and LILRB2) in the training sets (GSE104948 and GSE108109) using the “rms” package in R language (Figure 8A). Here, ITGB2 is linked to ganglioneuroma.