TNF and systemic lupus erythematosus: The results demonstrated that the CGs were negatively linked to the immune pathways (TNF signaling pathway, B cell receptor signaling pathway, and Th1/Th2/Th17 cell differentiation) in VTE (Figure 2E) and were positively linked to the immune responses (TNF signaling pathway, IL-17 signaling pathway, and NOD-like receptor signaling pathway) in SLE (Figure 2F).