CDK1 and colonic neoplasm: For instance, miR-26b overexpression in colon cancer cells can restrain the growth of colon cancer cells and promote apoptosis(16); Similarly, miR-769 targets CDK1 to regulate colon cancer cell proliferation and apoptosis(17), while ectopic expression of -133b leads to G1 phase cell cycle arrest and directly induces colon cancer cell apoptosis (18).