TNFSF14 and systemic sclerosis: This finding further asserts the role of LIGHT as a key regulator of fibrosis as the stimulation of IL-6 production by dermal fibroblasts would result in increased cellular activation, promoting both inflammation and fibrosis, and LIGHT suppression of Th1 chemokines is consistent with the fact that SSc is characterized by Th2/Th17 polarization.