KEGG was mainly enriched in the pathways of lipids and atherosclerosis, cancer, AGE-RAGE signaling pathway in diabetic complications, NOD-like receptor signaling pathway, coronavirus disease (COVID-19), Salmonella infection, Chagas disease, HIF-1 signaling pathway, plague infection, fluid shear stress, atherosclerosis, tuberculosis, Kaposi’s sarcoma-associated herpesvirus infection, diabetic cardiomyopathy, PI3K-Akt signaling pathway, insulin resistance, toxoplasmosis, hepatitis B, pathogenic E. coli infection, shigellosis, and MAPK signaling pathway. The gene discussed is RENBP; the disease is escherichia coli infection.