For example, Fazi et al. reported that in patients with acute myeloid leukemias, the recruitment of chromatin remodeling enzymes by AML1/ETO to the AML1 binding site on the pre-miR-223 gene results in the induction of heterochromatic silencing of miR-223 (39). The gene discussed is RUNX1; the disease is acute myeloid leukemia.