In addition to targeting NLRP3, in a model of pulmonary arterial hypertension (PAH), miR-223 can suppress the expression of the Integrin-β 3 subunit gene (ITGB3) to alleviate the progression of PAH and avoid the dysfunction of pulmonary arterial endothelial cells (90). Here, ITGB3 is linked to pulmonary arterial hypertension.