Further analyses of circulating cytokine levels in these leukemia patient plasma samples via Luminex multiplex assay found a correlation between sSig15 and the cytokines MCP-1/CCL2 and IL6 (Fig. 4C), which have been demonstrated to support the formation of the proleukemic bone marrow microenvironment (34, 35). The gene discussed is IL6; the disease is leukemia.