EGFR and lip and oral cavity carcinoma: Recently, Ling et al. used DSPE–PEG5K–COOH to wrap NIR-II dye SQ890 to form nanoparticles, and modified EGFR targeting peptide (GE890) on its surface, which can accurately target to the tumor site, so as to realize photoacoustic (FA)/NIR-II fluorescence dual-mode imaging to guide PTT to treat oral cancer (Fig. 4A).87 As shown in Fig. 4B, compared with L-02 cells with low EGFR expression, the nanoparticles modified by targeted peptides have more uptake in CAL 27 cells with high EGFR expression.