The silica shell can protect MNPs from chemical degradation in the body, avoid the leakage of harmful substances in the nucleus, and reduce the toxic and side effects on normal tissues.117 Tabasi et al. developed CD44-modified superparamagnetic Fe3O4/mesoporous silica nanocarriers (NCs-OXA) for the delivery of oxaliplatin (OXA) to HCT-116 colon cancer cells.118 They found that OXA was more lethal to HCT-116 cells, which was due to the interaction of CD44 receptors with NH2-groups to increase the intracellular uptake of NCs-OXA. This evidence concerns the gene CD44 and malignant colon neoplasm.