TP53 and ovarian carcinoma: Rajesh Kotcherlakota et al. designed a cationic gold nanoparticle functionalized with monoclonal antibody EGFR (C225) and wild type p53 plasmid DNA (p53DNA) for targeted gene delivery to ovarian cancer (Fig. 7A).80 The intracellular uptake of Au-C225-p53DNA was observed in SKOV-3 cells (human ovarian cancer) and CHO cells (china hamster ovary), respectively.