EGFR and lung cancer: Wang et al. functionalized the surface of PEGylated SPIO nanoparticles with an anti-EGFR monoclonal antibody (cetuximab) for targeted delivery to EGFR-overexpressing lung cancers.115 Compared with non-targeting PEGylated SPIO NPs, anti-EGFR-PEG-SPIO NPs exhibited better targeting ability to H460 tumor cells and enhanced targeted tissue thermogenesis by magnetic resonance-guided focused ultrasound surgery (MRgFUS) therapy.