Yong Il Park et al. constructed a FRβ-targeted pH-sensitive liposome (FRβ-pH lipo) to deliver doxycycline and docetaxel to better inhibit tumor growth in non-small cell lung cancer (NSCLC).77 It was observed by laser confocal that in FRβ overexpressed A549 cells, the fluorescence signal of folate-modified FRβ-pH lipo-Cy5.5 was 7.23 times stronger than that of NH2-pH lipo-Cy5.5. This evidence concerns the gene FOLR2 and non-small cell lung carcinoma.