Our umbrella review suggests that ginseng has beneficial effects on health outcomes, including metabolic indicators (e.g., TC, TG, LDL-C, HDL-C, FBG, HOMA-IR, BW,WC, BMI, SBP, DBP), inflammatory markers (e.g., IL-6 and TNF-α), fatigue and exercise endurance, seasonal upper respiratory infections, colds, sexual function, female menopausal symptoms, unstable angina as well as NSCLC and related complications. This evidence concerns the gene TNF and angina unstable.