Our umbrella review suggests that ginseng has beneficial effects on health outcomes, including metabolic indicators (e.g., TC, TG, LDL-C, HDL-C, FBG, HOMA-IR, BW,WC, BMI, SBP, DBP), inflammatory markers (e.g., IL-6 and TNF-α), fatigue and exercise endurance, seasonal upper respiratory infections, colds, sexual function, female menopausal symptoms, unstable angina as well as NSCLC and related complications. Here, IL6 is linked to non-small cell lung carcinoma.