During plant infection with the pathogenic fungus Magnaporthe grisea, there is a requirement for ROS generation which is mediated by the fungal tetraspanin Pls1 and an NADPH oxidase (Clergeot et al., 2001; Veneault-Fourrey et al., 2005; Moribe et al., 2012; Moribe and Mekada, 2013; Siegmund et al., 2013). Here, FMO5 is linked to infection.