IL1RN and IL10 have anti-inflammatory functions, IL1 promotes inflammation, carcinogenesis and anti-tumor immunity (Mantovani et al., 2019), IL6 is pro-tumoral by activating carcinogenesis and tumor outgrowth (Jones and Jenkins, 2018), and IL10 promotes cytotoxicity but inhibits anti-tumor activities (Ouyang and O'Garra, 2019). Here, IL1B is linked to neoplasm.