VEGFA and neoplasm: After the tumor tissue is heated, the gene expression and protein synthesis of VEGF are significantly inhibited, inhibiting the proliferation of endothelial cells and the formation of tumor neovascularization, while increasing the permeability of the cell membrane, making it easy for drugs to enter the tumor cells, and maintaining a high concentration of drugs in the cells, thereby improving the killing effect of tumors [27, 28].