The results showed that CTC counts (HR = 1.3, p < 0.001), Claudin-4 (HR = 4.6, p = 0.008), and lymph node metastasis (HR = 12.9, p = 0.001) were independent prognostic factors for poor prognosis (Table 6). The gene discussed is CLDN4; the disease is metastatic malignant neoplasm in the lymph nodes.