In general, calcium gluconate is considered to be safer when administered peripherally; however, one study performed in the setting of a calcium gluconate shortage showed a minimal number of complications when calcium chloride was administered peripherally.7 Shortly after that, potassium can be shifted intracellularly by the function of insulin on cellular membrane channels and beta agonism, typically with nebulized albuterol.8 The use of potassium losing diuretics, cation exchange resins, and sodium bicarbonate are common adjunctive treatments for hyperkalemia. This evidence concerns the gene INS and Hyperkalemia.