It is known that one of the key Th1-cytokines is IFN-γ, involvedin the many features regulation of asthma pathogenesis,including suppression of the of Th2 profile cytokine release,inhibition of the recruitment of effector cells to the site ofinflammation, apoptosis induction of T-cells, eosinophils, etc. Nevertheless, there have currently been a limited number ofstudies investigating the role of polymorphic sites in the IFNGin the pathogenesis of asthma. Here, IFNG is linked to asthma.