As a result of analysis of the IL4 rs2243250 and IL13rs1800925 distribution depending on the severity of asthma,a high frequency of both the CT genotypes of IL4 rs2243250and TT genotypes of IL13 rs1800925 in the group with severeasthma relative to the control group was noted, and for theСТ genotype of IL4 rs2243250, in the group of children withmild asthma ( p <0.05). This evidence concerns the gene IL4 and asthma.