LEMD3 and osteopetrosis: Osteopoikylosis, Buschke–Ollendorff syndrome, andmelorheostosis are benign and more often asymptomaticconditions of osteopetrosis, diagnosed more often radiologically,and caused by mutations in the LEMD3 gene.LEMD3 is an integral protein of the inner nuclear membrane.It contains a nucleoplasmic N- and C-terminal domainand two helical transmembrane segments.