TRAF6 and osteopetrosis: It is likely thatthese regions are regulatory; in fact, at the protein level,their deletion completely abolishes TRAF6 production.This mutation has been described in a single family, andthe osteopetrosis was not generalized, but was pronouncedin the pelvis and legs; because both patients, brother andsister, died at a very young age due to a severe immunologicaldefect, it is currently difficult to predict the evolutionof the disease in this particular case (Weisz Hubshman etal., 2017).