HLA-C and neoplasm: A few years later, this hypothesis was further strengthened since structural allelic variants and expression of this gene were linked to aggressive neoplasms in nasopharyngeal and cervical cancer, both caused by viruses, raising the possibility that the interaction of HLA-C/KIR as an innate immune response is involved in activity and viability of cancerous cells (Butsch Kovacic et al., 2005; Martin et al., 2010).