HLA-C and systemic lupus erythematosus: In the case of lupus, it was found that individuals with the HLA-C1 allele or carriers of HLA-C*17:01 are susceptible to this disease, apparently due to a greater expression of the HLAC1/KIR2DS2 ligand, resulting in an increased cytoplasmic antioxidant response due to oxidative stress in patients with systemic lupus erythematosus (Gambino et al., 2018; Hanscombe et al., 2018).