The allele HLA-C*06:02 executes an autoimmune response against ADAMTS-like protein five presented to CD8+ T-cells as a causative melanocyte autoantigen; together, the allele, the autoantigen, and the T cell receptor (TCR) trigger a psoriasis autoimmune response (Arakawa et al., 2021). The gene discussed is CD8A; the disease is psoriasis.