During the 2020 outbreak caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), polymorphisms in HLA-C were correlated with a higher mortality rate due to viral infection by triggering an overactive immune response SWED4Wlinked to the KIR mechanism of NK cells (Wang et al., 2020a; Sakuraba et al., 2020; Khor et al., 2021). The gene discussed is HLA-C; the disease is viral infectious disease.