The DEGs between WT and IL-17A treated STAT3 mice included S100a protein family such as S100a8 (calgranulin A, MRP-8) and S100a9 (calgranulin B, MRP-14), small proline-rich protein 2 (Sprr2) family such as Sprr2e, Sprr2g and Sprr2d, late cornified envelope-3 (LCE) genes such as LCE3d, LCE3e and LCE3f, et al. Some of the DEGs found in STAT3 mice compared with WT mice have been previously reported to be involved in psoriasis, such as IL-1β and chemokine (C-C motif) ligand (CCL) 4. Here, SPRR2G is linked to psoriasis.