Notably, the most significant pathways include ‘IL-17 signaling pathway’, ‘Coronavirus disease-COVID-19’, ‘Viral protein interaction with cytokine and cytokine receptor’, ‘Lipid and atherosclerosis’, ‘Toll-like receptor signaling pathway’, ‘C-type lectin receptor signaling pathway’, ‘NOD-like receptor signaling pathway’, ‘Cytokine-cytokine receptor interaction’, ‘NF-kappa B signaling pathway’, ‘Chemokine signaling pathway’ and ‘TNF signaling pathway’. The gene discussed is TNF; the disease is COVID-19.