This group showed a similar range in number of diseases/conditions, level of medication usage, and the five most popular medications were identical to that of the groups with severe periodontal disease, HMG-CoA reductase inhibitors (atorvastatin), selective serotonin uptake inhibitors (citalopram), Angiotensin-converting enzyme inhibitors (lipsinopril), metformin, and aspirin. Here, ACE is linked to periodontal disorder.