The specific proteins for AD are associated with a wide range of functions: stress response (Heat Shock 70 kDa Protein Cognate 4, Supplementary Figure S1A: No. 24), structural components of microtubules (Tubulin beta-1 and alpha-1 Chains, Supplementary Figure S1B: No. 26 and 27), lipid transport during insect flight (Apolipophorin-III, Figure 1: No. 15), core components of nucleosome (Histone H2B and Histone H4, Supplementary Figure S1B: No. 37 and 39), and ATP-Phosphotransferase (Arginine Kinase, Supplementary Figure S1B: No. 29). The gene discussed is TUBB1; the disease is Alzheimer disease.