Among 17 kinase gene fusions, three novel gene fusions have not been documented, including two in-frame gene fusions between RET and other genes (GRIPAP1 and intergenic region of GRAMD3) and one in-frame gene fusion between BRAF and PAK1. GRIPAP1 encodes a guanine nucleotide exchange factor for the Ras family of small G proteins, which has been reported as a partner gene of TFE3 in translocation renal cell carcinoma (26). This evidence concerns the gene RET and MIT family translocation renal cell carcinoma.