(127), i.p. administration of Rhynchophylline (Rhy) (10 or 20 mg/kg), an alkaloid found in the Uncaria species, to Aβ1-42-induced AD mice resulted in amelioration of cognitive impairment, limiting oxidative damage by reducing ROS, MDA and GSH levels and restoring the expression of NRF2 and the antioxidant enzymes it regulates in the frontal cortex and hippocampus of mice. The gene discussed is NFE2L2; the disease is Alzheimer disease.