AKT1 and Alzheimer disease: (142), who investigated the therapeutic effects of the extract of Ginkgo biloba 761 (EGb761) against Aβ-induced cell damage in an in vitro model of AD, it was found that EGb761 (25, 50, 100 and 250 μg/ml) resulted in ameliorating cell damage by inhibiting apoptosis, reducing ROS production and blood-brain barrier permeability, while enhancing the expression of Akt, NRF2 and HO-1.