NFKB1 and Cognitive impairment: • Decreased lipid peroxidation, iron deposition, IL-6, NO, IL-1, NF-kB signaling, ferroptosis, neuroinflammation• Increased mitochondrial activity, dopaminergic signaling, anti-inflammatory cytokines• Improvement of memory and cognitive deficits• Reduced Aβ deposition and p-tau in the brain