A study in AD rats administered with Benincasa hispida fruit extract, an extract rich in alkaloids, flavonoids, vitamins, volatile polysaccharides, hemicellulose polysaccharides, terpenes, sterols, amino acids and fatty acids (145), in doses of 250 and 500 mg/kg/day for a period of 16 days, showed, among other findings, that the antioxidant genes Keap1/NRF2/HO-1 were upregulated (146). The gene discussed is HMOX1; the disease is Alzheimer disease.