For example, FOXC1 and NFATC1 transcription factors (TFs) have been implicated in the regulation of HF-SC aging, through the control of quiescence, cell adhesion and extracellular matrix (ECM) (Keyes et al., 2013; Lay et al., 2016; Zhang et al., 2021). Here, FOXC1 is linked to hydrops fetalis.