Interestingly, the regions in old HF-SCs were enriched for the motif of Lhx2 (Figure 5F), which is required for quiescence control and cell fate maintenance of HF-SCs (Folgueras et al., 2013), whereas the regions enriched in young HF-SCs harbor Jun and Fosl2 motifs (Figure 5G). This evidence concerns the gene JUN and hydrops fetalis.