To probe more deeply into the transcriptomic changes along the bifurcating trajectory, we examined the 6 months branch, which represent the telogen (P53) to anagen (6 months) transition, and the 24 months branch, which represent the aging trajectory of typical telogen HF-SCs, by using Monocle3 (Cao et al., 2019) (Supplementary Figures S2C, D). Here, TP53 is linked to hydrops fetalis.