Dysregulation of phase transitions of biomolecule condensates is linked to a series of pathogenic conditions, including the toxicity induced by the liquid‒solid transition of ALS/FTD mutations in FUS (R522G, R524S, P525L, and R495X)[19] and the promotion of tumorigenesis for gain of PS properties, such as NUP98 fusion oncoproteins (NUP98-HOXA9 and NUP98-KDM5A) in leukemic transformation[95]. Here, FUS is linked to amyotrophic lateral sclerosis.