MAPT and neurodegenerative disease: Considering these findings, and given that (i) ALS exists along a spectrum with FTD [92]; (ii) a portion of PD risk is mediated by variation near the MAPT locus [93, 94]; and (iii) ALSP can manifest clinically as FTD [18], our finding of reduced NC monocytes in familial tauopathy both strengthens and extends the purported relevance of this monocyte population in neurodegenerative disease.