More broadly, in the experimental autoimmune encephalomyelitis model of multiple sclerosis, NK cell migration into the CNS is mediated in part by CX3CR1-dependent recruitment [101, 102], suggesting that the differential expression of CX3CR1 in NK cells that we observed in our study could plausibly affect NK cell recruitment to the CNS in primary tauopathy. This evidence concerns the gene CX3CR1 and multiple sclerosis.