In particular, NK cells had a large number of DEGs with LFC > 0.2, and our findings implicating CX3CR1 expression not only in NC monocytes but also in NK cells as a candidate peripheral biomarker of familial tauopathy is complemented by recent research suggesting an important yet previously unappreciated role for NK cells in a mouse model of AD [99]. This evidence concerns the gene CX3CR1 and Alzheimer disease.