Based on the TCGA database we found 8 differentially expressed Annexins between RCC and normal kidney tissues, including ANXA1, ANXA2R, ANXA3, ANXA4, ANXA8, ANXA8L1, ANXA9 and ANXA13. Among them, mRNA expression level of ANXA1, ANXA2R, ANXA4, ANXA8, ANXA8L1 and ANXA13 were significantly upregulated, while ANXA3 and ANXA9 were significantly downregulated in RCC compared with normal kidney tissues (Fig. 1). This evidence concerns the gene ANXA3 and renal cell carcinoma.