NLRP3 inflammasome then cleaves pro-IL-1β to generate mature IL-1β, which produces pro-inflammatory effect and contributes to gout pain by either directly activating or sensitizing peripheral nociceptors, including upregulating the pain-sensing transient receptor potential cation channel subfamily V member 1 (TRPV1) channel [10]. The gene discussed is TRPV1; the disease is gout.