DCN and neoplasm: We then injected CT26 cells combined with Dcn-KD or wildtype Raw264.7 cells (CT26: Raw264.7 = 10:1) treated with or without B.adolescentis (MOI = 10:1) into BALB/c nude mice, and found that B.adolescentis-treated Raw264.7 obviously impeded tumor growth, whereas knockdown of Dcn notably diminished the tumor suppressive effect of B.adolescentis on CRC (Fig. 3J-L).