Overexpressed, hyperphosphorylated Fra-1 entails transcriptional reprogramming of cancer cells, affecting biological processes such as cell division and survival, apoptosis, cellular plasticity, epithelial-to-mesenchymal transition (EMT), motility, invasion, metastatization and chemo- or radioresistance [9–13, 23–26]. The gene discussed is FOSL1; the disease is cancer.