As an approach to tackle this multifaceted issue in a context where gene regulation through coordinated action of multiple distal regulatory elements remains understudied, we employed a particularly well-suited model system consisting of TGFB2 gene down-regulation by the Fra-1 TF in Fra-1-overexpressing cancer cells, as Fra-1 binds to the numerous enhancers contacting the TGFB2 gene promoter. This evidence concerns the gene TF and cancer.