Based on that, a genomic classification of cutaneous melanoma into four subtypes is proposed: i) BRAF subtype (~ 50% of cutaneous melanomas; activating BRAF mutations; BRAFMut), ii) RAS subtype (20–30%; activating mutations in the RAS isoforms NRAS, HRAS and KRAS; RASMut), iii) NF-1 subtype (10–15%; loss-of-function mutations of NF-1; NF-1LOF) and iv) triple wild-type (WT) subtype (10–15%; absence of NF-1, BRAF or RAS mutations). This evidence concerns the gene NF1 and cutaneous melanoma.