Our findings showed that BHE and betanin can stimulate the intrinsic and extrinsic apoptosis pathways in HT-29 and Caco-2 cancer cell lines via downregulation of Bcl-2 and upregulation of BAD and Caspase-9 genes and also upregulation of Fas-R, Caspase-3, and Caspase-8, respectively. This evidence concerns the gene CASP8 and cancer.