CRP and Hyperintensity of cerebral white matter on MRI: Second, several factors which had been shown to pertain to the presence of cognitive deficits and/or depressive symptoms in rheumatic diseases (e.g., white matter hyperintensities, vasculopathy, cerebral calcifications, cerebral hypoperfusion, carotid artery intima media thickness, c-reactive protein) [7] were not taken into account.