PLIN3 and hepatocellular carcinoma: LDs have been recognized as the site for autophagosome biogenesis [37], and chaperone-mediated autophagy (CMA) is required to degrade PLIN3 before the selective sequestration of LDs by the autophagosome, which means that before autophagosome biogenesis associated and initiated by ATGs, PLIN3 would have to be removed from LDs surface [38], but the specific function of this mechanism on HCC development need to be further investigated.