Among them, ACSL3, AIFM2, HILPDA, HSD17B7, LPCAT1, LSS, PLIN3 and RAB10 were upregulated and CIDEB, G0S2, HSD17B13, PLIN1 and PLIN2 were downregulated in HCC tissues compared to normal tissues based on GEPIA database. The gene discussed is HSD17B13; the disease is hepatocellular carcinoma.