Although some studies have revealed that some LDs localized proteins has aberrant transcription and prognostic value in HCC, such as ACSL3 [20], HSD17B13 [21] or Rab10 [22], there are still few studies focusing on the panoramic value of LDs localized proteins in HCC progression, especially in NAFLD-accompanying HCC. The gene discussed is ACSL3; the disease is hepatocellular carcinoma.