Secondly, adipocyte-derived factor, the metabolic alteration in adipose tissue in the setting of obesity, results in an elevated circulating level of adipocyte-derived inflammatory cytokines, enclosing tumor necrosis factor-α, interleukin-6, angiotensinogen, and aldosterone-stimulating factors [38]. Here, IL6 is linked to obesity due to melanocortin 4 receptor deficiency.