It was reported that the RANKL-induced OCs differentiation was ameliorated by aconine through inhibiting the activation of the NF-κB signaling pathway and the downstream NFATc1 [45], indicating that the NF-κB pathway played an indispensable role in the maturation of OCs and the development of osteoporosis. The gene discussed is NFATC1; the disease is osteoporosis.