As can be seen, the key targets that were closely associated with the role of FZD in the intervention of osteoporosis included IL-1B, PTGS2, AKT1, CASP3, PPARG, CAT, IFNG, ESR1, HMOX1, and VCAM1 (Fig. 3C, D). This evidence concerns the gene VCAM1 and osteoporosis.