LETM1 and psychotic disorder: Again by the same group, a significant decrease in mitochondrial functional protein levels such as ATP synthase, mitofusin 2, and cyclophilin in astrocyte and neuron-derived exosomes in patients with first-episode psychosis in astrocyte-derived extracellular vesicles and NDEVs [119] and altered levels of mitochondrial calcium ion channel proteins such as an increased level of CACNA- 1C and decreased levels of LETM1, NCLX, SLC24A6, and TRPM4 in plasma NDEVs of patients with first-episode psychosis [120] have been reported.