In the present study, we have reported that Wg/Wnt1 and Erasp were previously unrecognized regulators of ER stress-induced apoptosis in Drosophila. Although several studies have described the Wnt signaling pathway as an essential pathway that regulates growth and is associated with development and cancer, to the best of our knowledge, none of those studies have identified Wnt as a mediator of ER stress-induced cell death. This evidence concerns the gene WNT1 and cancer.