CD33 and acute myeloid leukemia: Speculatively, based on the clinical efficacy of anti-CD33 targeting in AML t(8;21) using gemtuzumab ozagamicin [46], a vector carrying the CRISPR-Cas9 payload, e.g. an AAV or a lipid nanoparticle, targeted toward CD33+ cells could be pursued in order to ensure high fidelity toward leukemic cells while potentially sparing healthy cells.