RUNX1T1 and cancer: However, given that we detected no functional (i.e., non-disrupted) RUNX1-RUNX1T1 sequence in the RX2-RXT1-treated THP-1 cells, we infer from these data that the presence of the disrupted RUNX1-RUNX1T1 sequence could be due to an event caused by the CRISPR-Cas9-mediated disruption of RUNX1 and RUNX1T1 in THP-1 followed by faulty NHEJ repair, commonly characterizing cancer cell lines.