MAPT and Alzheimer disease: The effect of the different AD/LB groups and the independent effects of all three pathologies (that is, LB, Aβ and tau) on longitudinal cognitive function were examined in linear mixed-effects (LME) models focusing on the interaction of time × AD/LB group (Fig. 3a–c) and time × pathology (absent/present; Fig. 3d–f).