Other models such as experimental autoimmune encephalomyelitis (EAE) in mice have shown that in B1KO and B2KO animals or mice pretreated with B1R blocker (DALBK) and B2R antagonist (HOE-140), a decrease in the CD69 + T cell population occurs [63]. This evidence concerns the gene BDKRB1 and experimental autoimmune encephalomyelitis.